CARRIER FUNCTION IN ANTI-HAPTEN IMMUNE RESPONSES
نویسندگان
چکیده
منابع مشابه
Carrier Function in Anti-hapten Immune Responses
Transfer of live lymphoid cells from BGG-immunized strain 2 guinea pigs into syngeneic animals primed with DNP-OVA prepares the recipients for a markedly enhanced secondary anti-DNP antibody response upon challenge with DNP-BGG. This phenomenon has been demonstrated when the recipients were challenged 1 day after cell transfer, but it was considerably more striking when an interval of 6 days wa...
متن کاملCarrier Function in Anti-hapten Antibody Responses
The studies reported here demonstrate that immunocompetent lymphoid cells from allogeneic donor guinea pigs stimulate the synthesis of anti-DNP and anti-OVA antibodies by recipients previously primed with DNP-OVA. This allogeneic effect occurs spontaneously in the absence of any further anti-genic challenge. Furthermore, the transfer of allogeneic cells prepares DNP-OVA-primed recipients for a ...
متن کاملCarrier-directed anti-hapten responses by b-cell subsets
The capacity of the trinitrophenyl (TNP) haptenic group, coupled to a series of chemically dissimilar carriers, to cross-stimulate putative T- dependent and T-independent murine B-cell subpepulations was determined by using an in vitro limiting dilution technique to generate primary IgM responses. It was found that TNP-Ficoll and TNP-dextran, two T- independent antigens with little or no polycl...
متن کاملEpitope-specific regulation. I. Carrier-specific induction of suppression for IgG anti-hapten antibody responses
The epitope-specific regulatory system selectively controls IgG antibody production to the individual (haptenic) determinants on a complex antigen. This system can be specifically induced to suppress primary and secondary IgG antibody responses to dinitrophenyl hapten (DNP) without interfering with antibody responses to epitopes on the carrier molecule on which the DNP is presented. Furthermore...
متن کاملImmune Response to a Hapten Coupled to a Nonimmunogenic Carrier
Cooperation between two or more cell types is an essential feature of the immune response to some antigens (1). These cell types are commonly referred to as thymus derived (T) and bone marrow derived (B). Furthermore, in the immune response to a hapten bound to a carrier protein these two cell types perform quite separate and distinct cooperative functions (2-5). The T cell is responsible for r...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1970
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.132.2.261